1) Load existing league tables
League RDS files found
|
Outcome
|
Path
|
|
TST
|
C:/Users/risha/OneDrive/Desktop/NMA/league_TST.rds
|
|
SOL
|
C:/Users/risha/OneDrive/Desktop/NMA/league_SOL.rds
|
|
WASO
|
C:/Users/risha/OneDrive/Desktop/NMA/league_WASO.rds
|
|
PSQI
|
C:/Users/risha/OneDrive/Desktop/NMA/league_PSQI.rds
|
|
SE
|
C:/Users/risha/OneDrive/Desktop/NMA/league_SE.rds
|
##
## ============ TST ============
## Column names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Row names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Is Placebo a column? TRUE
## Is Placebo a row? TRUE
##
## First few rows and columns:
## Placebo Ashwagandha
## Placebo Placebo 10.61 (0.42 to 23.42)
## Ashwagandha -10.61 (-23.42 to -0.42) Ashwagandha
## Melatonin-IR -11.62 (-26.42 to 0.64) -1.10 (-15.85 to 13.45)
## Melatonin-IR
## Placebo 11.62 (-0.64 to 26.42)
## Ashwagandha 1.10 (-13.45 to 15.85)
## Melatonin-IR Melatonin-IR
##
## ============ SOL ============
## Column names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Row names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Is Placebo a column? TRUE
## Is Placebo a row? TRUE
##
## First few rows and columns:
## Placebo Ashwagandha
## Placebo Placebo -4.60 (-7.36 to -1.17)
## Ashwagandha 4.60 (1.17 to 7.36) Ashwagandha
## Melatonin-IR 6.31 (2.27 to 10.83) 1.74 (-2.19 to 6.81)
## Melatonin-IR
## Placebo -6.31 (-10.83 to -2.27)
## Ashwagandha -1.74 (-6.81 to 2.19)
## Melatonin-IR Melatonin-IR
##
## ============ WASO ============
## Column names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Row names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Is Placebo a column? TRUE
## Is Placebo a row? TRUE
##
## First few rows and columns:
## Placebo Ashwagandha Melatonin-IR
## Placebo Placebo -2.38 (-8.65 to 3.14) -3.05 (-12.30 to 3.57)
## Ashwagandha 2.38 (-3.14 to 8.65) Ashwagandha -0.69 (-9.97 to 6.75)
## Melatonin-IR 3.05 (-3.57 to 12.30) 0.69 (-6.75 to 9.97) Melatonin-IR
##
## ============ PSQI ============
## Column names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Valerian
## Row names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Valerian
## Is Placebo a column? TRUE
## Is Placebo a row? TRUE
##
## First few rows and columns:
## Placebo Ashwagandha Melatonin-IR
## Placebo Placebo -0.80 (-1.96 to 0.41) -0.75 (-1.83 to 1.27)
## Ashwagandha 0.80 (-0.41 to 1.96) Ashwagandha 0.05 (-1.18 to 2.19)
## Melatonin-IR 0.75 (-1.27 to 1.83) -0.05 (-2.19 to 1.18) Melatonin-IR
##
## ============ SE ============
## Column names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Row names: Placebo Ashwagandha Melatonin-IR Melatonin-PR Tart-cherry Valerian
## Is Placebo a column? TRUE
## Is Placebo a row? TRUE
##
## First few rows and columns:
## Placebo Ashwagandha Melatonin-IR
## Placebo Placebo 2.99 (1.18 to 4.54) 3.01 (0.65 to 5.39)
## Ashwagandha -2.99 (-4.54 to -1.18) Ashwagandha 0.00 (-2.21 to 2.60)
## Melatonin-IR -3.01 (-5.39 to -0.65) -0.00 (-2.60 to 2.21) Melatonin-IR
2) Build tidy effects vs Placebo
Effects vs reference by outcome (MD, 95% CrI)
|
outcome
|
treatment
|
md
|
lCrI
|
uCrI
|
|
PSQI
|
Ashwagandha
|
-0.80
|
-1.96
|
0.41
|
|
PSQI
|
Melatonin-IR
|
-0.75
|
-1.83
|
1.27
|
|
PSQI
|
Melatonin-PR
|
-0.63
|
-1.94
|
0.77
|
|
PSQI
|
Valerian
|
-5.27
|
-7.49
|
-3.03
|
|
SE
|
Ashwagandha
|
2.99
|
1.18
|
4.54
|
|
SE
|
Melatonin-IR
|
3.01
|
0.65
|
5.39
|
|
SE
|
Melatonin-PR
|
3.37
|
-1.43
|
8.14
|
|
SE
|
Tart-cherry
|
2.47
|
-2.66
|
7.70
|
|
SE
|
Valerian
|
0.55
|
-3.44
|
4.41
|
|
SOL
|
Ashwagandha
|
-4.60
|
-7.36
|
-1.17
|
|
SOL
|
Melatonin-IR
|
-6.31
|
-10.83
|
-2.27
|
|
SOL
|
Melatonin-PR
|
-7.92
|
-13.47
|
-2.50
|
|
SOL
|
Tart-cherry
|
-2.26
|
-13.65
|
9.08
|
|
SOL
|
Valerian
|
1.57
|
-3.76
|
7.39
|
|
TST
|
Ashwagandha
|
10.61
|
0.42
|
23.42
|
|
TST
|
Melatonin-IR
|
11.62
|
-0.64
|
26.42
|
|
TST
|
Melatonin-PR
|
6.96
|
-8.04
|
21.65
|
|
TST
|
Tart-cherry
|
28.93
|
-3.89
|
62.94
|
|
TST
|
Valerian
|
0.41
|
-18.69
|
19.86
|
|
WASO
|
Ashwagandha
|
-2.38
|
-8.65
|
3.14
|
|
WASO
|
Melatonin-IR
|
-3.05
|
-12.30
|
3.57
|
|
WASO
|
Melatonin-PR
|
5.30
|
-10.98
|
21.15
|
|
WASO
|
Tart-cherry
|
-11.84
|
-39.98
|
16.41
|
|
WASO
|
Valerian
|
-5.18
|
-14.69
|
6.39
|
3) Cross-outcome matrix
## TST significance check:
## # A tibble: 5 × 7
## treatment md lCrI uCrI sig sig_check crosses_zero
## <chr> <dbl> <dbl> <dbl> <lgl> <lgl> <lgl>
## 1 Ashwagandha 10.6 0.42 23.4 TRUE TRUE FALSE
## 2 Melatonin-IR 11.6 -0.64 26.4 FALSE FALSE TRUE
## 3 Melatonin-PR 6.96 -8.04 21.6 FALSE FALSE TRUE
## 4 Tart-cherry 28.9 -3.89 62.9 FALSE FALSE TRUE
## 5 Valerian 0.41 -18.7 19.9 FALSE FALSE TRUE
##
## === ACTUALLY SIGNIFICANT EFFECTS ===
## # A tibble: 7 × 5
## treatment outcome md lCrI uCrI
## <chr> <chr> <dbl> <dbl> <dbl>
## 1 Valerian PSQI -5.27 -7.49 -3.03
## 2 Ashwagandha SE 2.99 1.18 4.54
## 3 Melatonin-IR SE 3.01 0.65 5.39
## 4 Ashwagandha SOL -4.6 -7.36 -1.17
## 5 Melatonin-IR SOL -6.31 -10.8 -2.27
## 6 Melatonin-PR SOL -7.92 -13.5 -2.5
## 7 Ashwagandha TST 10.6 0.42 23.4
##
## === CLINICALLY MEANINGFUL (Exceeds MCID) ===
## # A tibble: 2 × 4
## treatment outcome md mcid
## <chr> <chr> <dbl> <dbl>
## 1 Valerian PSQI -5.27 4.4
## 2 Tart-cherry TST 28.9 15
